Selected Publications

* Contributed equally

Xu TH, Liu M, Zhou XE, Liang G, Zhao G, Xu HE, Melcher K, Jones PA. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature. 2020;586(7827):151-5. doi: 10.1038/s41586-020-2747-1 

Xu TH, Liu M, Zhou XE, Liang G, Xu HE, Melcher K, Jones PA, editors. The nucleosomal acidic patch helps anchor of de novo DNA methyltransferase DNMT3A2/3B3 complex. Cancer Research; 2020: American Association for Cancer Research. doi:10.1158/1538-7445.AM2020-1078

Thomas SL*, Xu TH*, Carpenter BL, Pierce SE, Dickson BM, Liu M, Liang G, Jones PA. DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding. Nucleic Acids Res. 2023. doi: 10.1093/nar/gkad293

Xing C*, Zhuang Y*, Xu TH*, Feng Z*, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. Cell. 2020;180(4):645-54 e13. doi: 10.1016/j.cell.2020.01.007 

Yang S, Wu Y*, Xu TH*, de Waal PW*, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature. 2018;560(7720):666-70. doi: 10.1038/s41586-018-0447-x

Yan Y*, Xu TH*, Harikumar KG, Miller LJ, Melcher K, Xu HE. Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites. J Biol Chem. 2017;292(38):15826-37. doi: 10.1074/jbc.M117.789669

Xu TH, Yan Y, Kang Y, Jiang Y, Melcher K, Xu HE. Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the Abeta42/Abeta40 ratio. Cell Discov. 2016;2:16026. doi: 10.1038/celldisc.2016.26

Yan Y*, Xu TH*, Melcher K, Xu HE. Defining the minimum substrate and charge recognition model of gamma-secretase. Acta pharmacol Sin. 2017;38(10):1412-24. doi: 10.1038/aps.2017.35

Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K. Structure of an AMPK complex in an inactive, ATP-bound state. Science. 2021;373(6553):413-9. doi: 10.1126/science.abe7565 

Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K, editors. Structure of the AMPK complex in its inactive ATP-bound state. PROTEIN SCIENCE; 2021: WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA 

Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, Melcher K, Xu HE. Amyloid beta: structure, biology and structure-based therapeutic development. Acta pharmacol Sin. 2017;38(9):1205-35. doi: 10.1038/aps.2017.28