Publications

Full publication list

* Contributed equally; # Correspondence

Selected Publications

1. Yan Y,  Zhou XE, Thomas SL, Liu M, Lai GQ, Worden EJ, Jones PA#, Xu TH#. Molecular Mechanisms of DNMT3A-3L-Mediated de novo DNA Methylation on Chromatin. bioRxiv. 2025. doi: 10.1101/2025.06.10.658647

2. Thomas SL*, Xu TH*, Carpenter BL, Pierce SE, Dickson BM, Liu M, Liang G, Jones PA. DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding. Nucleic Acids Res. 2023. doi: 10.1093/nar/gkad293

3. Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K. Structure of an AMPK complex in an inactive, ATP-bound state. Science 373. 2021. doi: 10.1126/science.abe7565 

4. Yan Y, Mukherjee S, Harikumar KG, Strutzenberg TS, Zhou XE, Suino-Powell K, Xu TH, Sheldon RD, Lamp J, Brunzelle JS, Radziwon K, Ellis A, Novick SJ, Vega IE, Jones RG, Miller LJ, Xu HE, Griffin PR, Kossiakoff AA, Melcher K, editors. Structure of the AMPK complex in its inactive ATP-bound state. PROTEIN SCI. 2021.

5. Xu TH, Liu M, Zhou XE, Liang G, Zhao G, Xu HE, Melcher K, Jones PA. Structure of nucleosome-bound DNA methyltransferases DNMT3A and DNMT3B. Nature 586, 2020. doi: 10.1038/s41586-020-2747-1 

6. Xu TH, Liu M, Zhou XE, Liang G, Xu HE, Melcher K, Jones PA, editors. The nucleosomal acidic patch helps anchor of de novo DNA methyltransferase DNMT3A2/3B3 complex. Cancer Research. 2020. doi:10.1158/1538-7445.AM2020-1078

7. Xing C*, Zhuang Y*, Xu TH*, Feng Z*, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ. Cryo-EM Structure of the Human Cannabinoid Receptor CB2-Gi Signaling Complex. Cell 180. 2020. doi: 10.1016/j.cell.2020.01.007 

8. Yang S, Wu Y*, Xu TH*, de Waal PW*, He Y, Pu M, Chen Y, DeBruine ZJ, Zhang B, Zaidi SA, Popov P, Guo Y, Han GW, Lu Y, Suino-Powell K, Dong S, Harikumar KG, Miller LJ, Katritch V, Xu HE, Shui W, Stevens RC, Melcher K, Zhao S, Xu F. Crystal structure of the Frizzled 4 receptor in a ligand-free state. Nature 560. 2018. doi: 10.1038/s41586-018-0447-x

9. Yan Y*, Xu TH*, Harikumar KG, Miller LJ, Melcher K, Xu HE. Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites. J Biol Chem 292. 2017. doi: 10.1074/jbc.M117.789669

10. Chen GF, Xu TH, Yan Y, Zhou YR, Jiang Y, Melcher K, Xu HE. Amyloid beta: structure, biology and structure-based therapeutic development. Acta pharmacol Sin. 38. 2017. doi: 10.1038/aps.2017.28

11. Yan Y*, Xu TH*, Melcher K, Xu HE. Defining the minimum substrate and charge recognition model of gamma-secretase. Acta pharmacol Sin 38. 2017. doi: 10.1038/aps.2017.35

12. Xu TH, Yan Y, Kang Y, Jiang Y, Melcher K, Xu HE. Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the Abeta42/Abeta40 ratio. Cell Discov 2. 2016. doi: 10.1038/celldisc.2016.26